New avenue to inhibit Ras signaling.
نویسنده
چکیده
Inhibition of Ras-stimulating enzymes is a possible avenue to treat Ras-driven diseases. In this issue of Chemistry & Biology, Evelyn and coworkers report an inhibitor for one such enzyme, Sos1, capable of impairing wild-type Ras signaling in cells.
منابع مشابه
Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase.
Mutations in the Ras family of GTP binding proteins represent one of the most frequently observed genetic alterations in human cancers. We and others have recently demonstrated that expression of Met, the tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), is significantly up-regulated in Ras-transformed cells. Because HGF/SF-Met signaling is proposed to play a promin...
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1. Abstract 2. Introduction 2.1. Mutated proteins can induce malignant transformation 2.2. Mutant ras-p21 Protein Is a Major Cause of Cancer 2.3. ras-induced signal transduction pathways 2.4. Direct interactions between ras-p21 and target proteins depends largely on two of its domains 2.5. How amino acid substitutions in ras-p21 can induce it to become oncogenic 3. Methods 3.1. Computational me...
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عنوان ژورنال:
- Chemistry & biology
دوره 21 12 شماره
صفحات -
تاریخ انتشار 2014